KEGG   REACTION: R06448
Entry
R06448                      Reaction                               
Definition
5 Methylmalonyl-CoA + 2 Malonyl-CoA + (2S)-Ethylmalonyl-CoA + 7 NADPH + 7 H+ <=> 8 CoA + Tylactone + 8 CO2 + 3 H2O + 7 NADP+
Equation
5 C02557 + 2 C00083 + C18026 + 7 C00005 + 7 C00080 <=> 8 C00010 + C12000 + 8 C00011 + 3 C00001 + 7 C00006
Comment
tylactone synthase,TylG1-5
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557  C00010_C18026
RC02829  C02557_C12000
RC02910  C02557_C12000
RC02911  C00083_C12000
RC02912  C00083_C12000
RC02914  C02557_C12000
RC02917  C02557_C12000
RC02919  C02557_C12000
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Orthology
K15988  tylactone synthase 1
K24555  tylactone synthase 2
K24556  tylactone synthase 3
K24557  tylactone synthase 4
K24558  tylactone synthase 5

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (9)   
   KEGG RCLASS (9)   
Gene (14)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (9)   
All databases (40)   

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